2 edition of Transmembrane signal transduction found in the catalog.
Transmembrane signal transduction
by U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, National Cancer Institute, International Cancer Research Data Bank, For sale by the Supt. of Docs., U.S. G.P.O. in Bethesda, MD, [Washington, DC
Written in English
|Other titles||Selected abstracts on transmembrane signal transduction.|
|Statement||Catherine A. O"Brian, consulting reviewer.|
|Contributions||O"Brian, Catherine A., 1957-, International Cancer Research Data Bank.|
|The Physical Object|
|Pagination||x, 135, 33, 7 p.|
|Number of Pages||135|
Most regulatory factors are water-soluble, interact with membrane receptors and induce a signal transduction process that leads to the formation of intracellular signals and to the stimulation of signalling cascades that result in the cellular reaction to the stimulus. Adenylyl Cyclases G-protein-coupled Receptors Guanylyl Cyclase Phospholipases. Mechanisms of Transmembrane Signal Transduction During B Cell Activation With K. Mark Coggeshall, John G. Monroe, John T. Ransom, John C. Cambier The ability of the B cell to distinguish among regulatory species is probably determined at multiple levels.
Signal transduction processes through membrane receptors involve the external reactions, in which the ligand binds to a membrane receptor, and the internal reactions, in which intracellular response is triggered.. Signal transduction through membrane receptors requires four parts: Extracellular signaling molecule: an extracellular signaling molecule is produced by one cell . The impact of environmental signals on the growth and survival of human T cells / Fernando A. Arosa [and others] --Novel single cell fluorescence approaches in the investigation ofsignaling at the cellular level / Péter Nagy [and others] --Non-random patterns of membrane proteins and their roles in transmembrane signaling / Andrea Bodnár [and.
Two-component signal transduction systems enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions. Signal transduction can occur through the transfer of phosphoryl groups from adenosine triphosphate (ATP) to a specific histidine residue in the histidine kinases (HK). Title:Transmembrane Phosphatases and Cancer Development, the Role of Protein Tyrosine Phosphatase-kappa (PTP) and Protein Tyrosine Phosphatase-mu (PTP) VOLUME: 8 ISSUE: 2 Author(s):Ping-Hui Sun, Lin Ye, Malcolm D D. Mason and Wen G. Jiang Affiliation:Metastasis & Angiogenesis Research Group, Institute of Cancer and Genetics, .
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Summarizing and structuring our current multidisciplinary knowledge in the field of signal transduction, this book significantly improves our overall molecular understanding of the operations of the receptor, cell and the entire system, and opens new perspectives in life sciences and biotechnology.
The previous edition of Transmembrane Signaling Protocols was published in Since then the human genome has been completely sequenced and new methods have been developed for the use of microarrays and proteomics to analyze global changes in.
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Conversion of a signal from one form into another is known as signal transduction, and in this part of the chapter we consider several different mechanisms of signal transduction in cell signaling. Cell-surface receptors activate intracellular signaling pathways and so convert an extracellular signal into an intracellular one that then Author: Charles A Janeway, Paul Travers, Mark Walport, Mark J Shlomchik.
This chapter presents a striking account of elements involved in signal transduction with specific reference to hormones. Despite excellent anatomical descriptions, almost Transmembrane signal transduction book was known about the functions of the various organs which constitute the endocrine system (glands) until the last decade of the 19th century.
Transmembrane signal transduction book Cutting-edge and highly practical, Transmembrane Signaling Protocols, Second Edition, makes available to novice and experienced researchers alike the readily reproducible techniques needed to advance the study of signal transduction pathways today.
Although family B G protein-coupled receptors (GPCRs) contain only 15 members, they play key roles in transmembrane signal transduction of hormones. Family B GPCRs are drug targets for developing therapeutics for diseases ranging from metabolic to neurological disorders.
Despite their importance, the molecular mechanism of activation of family B GPCRs remains largely. Starting from the principles of gene regulation and regulation of enzyme activity, the topics of this book cover function, structure, and integral construction of signalling pathways plus a detailed description of the various types of carriers such as second messengers, protein kinases, and transmembrane receptors.
Part of the Methods in Molecular Biology book series (MIMB, volume ) Abstract. Like all living organisms, bacteria must communicate with the world around them. Manson M.D. () Transmembrane Signal Transduction in Bacterial Chemosensing. In: Manson M. (eds) Bacterial Chemosensing.
Methods in Molecular Biology, vol Humana Press. Thus, signal-transduction pathways that include 7TM receptors, the activation of adenylate cyclase, and the activation of PKA can modulate enzyme activities, gene-expression patterns, and membrane excitability.
By agreement with the publisher, this book is accessible by the search feature, but cannot be browsed. The Hedgehog (Hh) signal transduction pathway is essential for the development and patterning of numerous organ systems, and has important roles in a variety of human cancers.
Genetic screens for mouse embryonic patterning mutants first showed a connection between mammalian Hh signaling and intraflagellar transport (IFT), a process required for.
In a new chapter, an introduction to signal transduction, the book provides a concise overview of receptor mechanisms, from receptor – ligand interactions to post-translational modifications operational in the process of bringing about cellular changes.
Transmembrane Signaling Protocols brings together a collection of practical, cutting-edge techniques for the study of cell signaling.
Written by acknowledged leaders in the field, the protocols provide detailed, step-by-step instructions, helpful notes, and troubleshooting tips that make even the most powerful of the latest techniques readily reproducible.
Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, which ultimately results in a cellular ns responsible for detecting stimuli are generally termed receptors, although in some cases the term sensor is used.
Essentially every biochemical process presented in the remainder of this book either is a component of a signal-transduction pathway or can be affected by one. As we shall see, the use of protein modulesin various combinations is a clear, even dominant, theme in the construction of signal-transduction proteins.
Transmembrane receptor kinases (RKs) mediate signal transduction pathways leading to cell proliferation, growth, and differentiation in animals. The crucial function of RKs is recognition of an extracellular ligand, which leads to activation of the intracellular kinase domain and subsequent transduction of downstream signaling pathways.
Publisher Summary Transmembrane signal transduction plays a central role in biology. All cells transport information from surface receptors into the cytoplasm where it is processed and used to regulate virtually every aspect of biological activity.
This is analogous to the uptake of nutrient molecules from the environment. G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein-linked receptors (GPLR), is a large group of evolutionary related proteins that are cell surface receptor that detect molecules outside the cell and activate cellular responses.
Coupling with G. Introduction to signal transduction provides an overview of the many mechanisms that cells employ to create a symbolic representation of their environment. It deals with first messengers (ligands) and receptors and how they interact, their basic pharmacology, and their modes of signal transmission into the cell.
This chapter focuses on signal transduction through transforming growth factor β1 (TGFβ1) receptors, which contain a transmembrane serine/threonine-protein kinase domain. On the basis of their structural and functional properties, the receptors for this family of ligands are divided into two subfamilies, type I and type II (TβR-I and TβR-II).
Cutting-edge and highly practical, Transmembrane Signaling Protocols, Second Edition, makes available to novice and experienced researchers alike the readily reproducible techniques needed to advance the study of signal transduction pathways today.\/span>\"@ en\/a> ; \u00A0\u00A0\u00A0\n schema:description\/a> \" Bioluminescence resonance.ISBN: X OCLC Number: Description: xi, pages: illustrations ; 24 cm.
Contents: Transmembrane signaling by G protein-coupled receptors / Louis M. Luttrell --Crosstalk coregulation mechanisms of G protein-coupled receptors and receptor tyrosine kinases / Kanchana Nataranjan and Bradford C.
Berk. Book. TOC. Actions. Share. Biochemistry of Signal Transduction and Regulation Signal Transmission via Transmembrane Receptors with Tyrosine‐Specific Protein Kinase Activity (Pages: ) Request permissions; CHAPTER no Intracellular Signal Transduction: The Protein Cascades of the MAP Kinase Pathways (Pages: ) .